The many roles of progesterone beyond endometrial protection
On the NHS and in a conventional medicine setting progesterone is still usually only considered for those who have a womb and are going to be prescribed oestrogen. There are a couple of exceptions where progesterone is indicated in women without a womb which is those who have a history of endometriosis and those who have had a sub total hysterectomy. However we know from the science and literature there are so many benefits of progesterone beyond those of endometrial protection. Read below for my further insights. As progesterone is so safe and given the many benefits and given progesterone is the first hormone to decline during perimenopause , I do feel it should be more available for patients to use and access without always needing to be given oestrogen first.
Calming the nervous system
Progesterone helps to calm the nervous system by converting to a molecule called allopregnenolone , AlloP which interacts with the GABA receptors which is calming and anti anxiety for the nervous system
Induces sleep and supports sleep quality
Oral micronized progesterone again by interacting with the GABA receptors is slightly sedative and there helps to both induce and stay asleep
Reduces night sweats
Progesterone has been shown to be very beneficial for night sweats in early perimenopause when oestrogen levels are already in fact 3-4x higher than in menstruating years and therefore further oestrogen is not ususally indicated
Cancer protective
Whilst oestrogen is proliferative and causes growth, progesterone is stabilising and anti proliferative in both endometrial and breast tissue
Heavy bleeding
To help counter the effects of raised/high oestrogen which is proliferative, progesterone can help to reduce /manage heavy bleeding in perimenopause
Endometriosis, adenomyosis, PMS, PCOS, PMDD, Migraines
I’m an independent prescribing pharmacist and registered nutritional therapist specialising in fertility and women’s health. If you’re ready to take control of your hormonal symptoms and find balance, learn more about me and how my unique approach can support your health here. As an independent prescriber and registered nutritional therapist, I blend scientific expertise with a holistic, functional medicine perspective to provide personalised care to my clients. To begin your hormone healing journey, head to my online booking form and apply to work with me in person at my Harley Street and Gerrards Cross clinic locations or online today.